609 Far ultraviolet-C radiation from a filtered KrCl lamp does not result in migration of Langerhans cells in human skin

There is global interest in both the beneficial and detrimental health effects of ultraviolet-C (UVC) radiation wavelength range 200-230 nm (known as Far-UVC). Technology using Far-UVC proposed a highly effective control measure for reducing transmission COVID-19. Far-UVC, other wavelengths UVC, are well-known to efficiently inactivate pathogens air on surfaces. Although studies have shown irradiation skin with 254 UV results DNA damage epidermal basal layer, (222 nm) shows minimal only granular which comprised non-proliferating keratinocytes. Therefore, accumulation these photoproducts would not be expected associated cancer risk. It has also been that even high doses exposure human do induce erythema. However, immune system are, best our knowledge, unknown. well-reported ultraviolet B (UVB 280-315 ultraviolet-A (UVA 315-400 cutaneous Langerhans cells (LC), inducing migration from epidermis draining lymph nodes, thereby suppressing function. Here we present data generated types (Fitzpatrick II-V) demonstrating little or no impact system, assessed by cell migration, at up 3,000 mJ/cm2 (US daily limit 450 mJ/cm2). These support safety filtered use, could transformative effect public health, allowing virus inactivation reduction independent behavior. Conflict disclosure: authors state conflict interest. MJC RPH directors Ten Bio Ltd, company focused developing explant models.